Creatine+

Jinfiniti’s Creatine+ is an unique product that combines two critical nutrients: creatine monohydrate and ATP. You get both ingredients for the price of one.  Other products only have creatine or ATP.

Combining creatine and ATP in a single product offers a synergistic effect that enhances the health benefits of each individual component. Here are the key health benefits of this combined product:

1. Enhanced Exercise Performance

• Increased Energy Supply: ATP serves as the immediate energy currency of the cell, and creatine helps replenish ATP stores during high-intensity exercise. This combination ensures a continuous and rapid supply of energy, improving performance during short, explosive activities like sprinting and weightlifting.
• Improved Muscle Strength and Power: The combined supplementation of creatine and ATP has been shown to significantly enhance muscle strength and power output, leading to better overall exercise performance and muscle gains.

2. Faster Muscle Recovery

• Reduced Muscle Fatigue: Creatine helps buffer lactic acid buildup in muscles, while ATP supports cellular repair and recovery processes. Together, they reduce muscle fatigue and soreness, allowing for quicker recovery between workouts.
• Enhanced Muscle Repair: The combination aids in the repair of damaged muscle tissues, promoting faster recovery and reducing the risk of injury from intense training sessions.

3. Improved Cognitive Function

• Increased Brain Energy Levels: Both creatine and ATP are involved in energy metabolism in the brain. Supplementation can enhance cognitive function, particularly in tasks requiring short-term memory and quick thinking, by ensuring an adequate energy supply to brain cells.
• Neuroprotective Effects: Creatine and ATP may have neuroprotective properties that support brain health and protect against neurodegenerative diseases. Creatine is a newly discovered neurotransmitter that facilitates neuronal cell communications.

4. Enhanced Cellular Health and Longevity

• Support for Mitochondrial Function: ATP is critical for mitochondrial function, and creatine supports ATP production. This combination can improve overall cellular energy metabolism, enhancing cell health and longevity.
• Reduced Oxidative Stress: Creatine has antioxidant properties, and together with ATP, it helps reduce oxidative stress and inflammation, contributing to better overall health.

Conclusion

The combined supplementation of creatine and ATP offers a powerful synergy that enhances exercise performance, accelerates muscle recovery, improves cognitive function, and supports overall cellular health. This combination can be particularly beneficial for athletes, older adults, and individuals looking to improve their physical and mental performance.

Yes, creatine levels do decline with age. Here are some key points and sources to support this information:

Key Points

1. Muscle Mass and Creatine Levels:

   • Muscle mass tends to decrease with age, a condition known as sarcopenia. Since creatine is stored in muscle tissue, a reduction in muscle mass leads to a corresponding decline in creatine stores.
   • This reduction in muscle creatine can contribute to decreased physical performance and increased fatigue in older adults.

2. Dietary Intake and Absorption:

   • Older adults might consume less dietary creatine because of changes in dietary habits or reduced appetite. Additionally, the efficiency of creatine absorption may decline with age.
   • Dietary sources of creatine include meat and fish, which some older adults may consume less frequently due to dietary restrictions or preferences.

3. Metabolic Changes:

   • The body’s ability to synthesize creatine might decrease with age. This decline in endogenous synthesis, combined with lower dietary intake, contributes to reduced overall creatine levels in the body.

Supporting Evidence

1. Scientific Studies:

   • A study published in the Journal of Applied Physiology found that older adults have lower muscle creatine concentrations compared to younger individuals. Supplementation with creatine can help restore these levels, improving muscle strength and function .
   • Another study in Aging Cell highlighted that creatine supplementation in older adults can improve muscle function, suggesting that creatine stores are indeed lower in this population and can benefit from supplementation .

2. Clinical Observations:

   • Clinical observations and trials have consistently shown that older adults experience significant benefits from creatine supplementation, including improvements in muscle mass, strength, and cognitive function. These benefits suggest that creatine levels are suboptimal in older populations and can be improved through supplementation.

Conclusion

Creatine levels decline with age due to factors like reduced muscle mass, lower dietary intake, and decreased endogenous synthesis. Supplementation can help counteract these declines, improving physical performance and overall health in older adults.

References

1. Journal of Applied Physiology
2. Aging Cell
3. PubMed: Creatine and Aging

Low creatine levels can lead to various signs and symptoms, primarily affecting physical performance, muscle function, and overall energy levels. Here are some common signs of low creatine levels:

Physical and Muscular Symptoms

1. Muscle Weakness and Fatigue:

   • Reduced creatine levels can lead to decreased muscle strength and endurance, making it more challenging to perform high-intensity activities or prolonged exercise sessions .

2. Decreased Muscle Mass:

   • Creatine plays a crucial role in muscle growth and maintenance. Low levels can contribute to muscle atrophy or a reduction in muscle mass, particularly noticeable in older adults .

3. Prolonged Recovery Time:

   • Individuals with low creatine levels may experience longer recovery times after physical activity, as creatine is essential for replenishing ATP stores and repairing muscle tissue .

Cognitive and Mental Symptoms

1. Mental Fatigue and Brain Fog:

   • Creatine is also involved in brain energy metabolism. Low levels can lead to symptoms such as mental fatigue, difficulty concentrating, and general cognitive decline .

2. Memory and Cognitive Function:

   • Some studies suggest that low creatine levels can impact memory and overall cognitive function, potentially exacerbating issues related to aging or neurological conditions .

Metabolic and General Health Symptoms

1. Low Energy Levels:

   • Creatine is a critical component in the production and recycling of ATP, the primary energy currency of the cell. Low creatine levels can result in general feelings of tiredness and reduced energy .

2. Reduced Exercise Performance:

   • Individuals with low creatine levels may notice a significant drop in their exercise performance, especially in activities that require short bursts of high-intensity effort, such as sprinting or weightlifting .

Specific Conditions

1. Conditions with Increased Creatine Demand:
   • Certain medical conditions, such as muscular dystrophy, heart failure, and other chronic diseases, can increase the body’s demand for creatine, making supplementation necessary to prevent deficiencies and support overall health .

Conclusion

Low creatine levels can affect various aspects of physical, cognitive, and overall health. Supplementation can help address these deficiencies, improving muscle function, energy levels, and cognitive performance.

References

1. Journal of the International Society of Sports Nutrition
2. Journal of Strength and Conditioning Research
3. Aging Cell
4. PubMed: Creatine and Aging
5. Mayo Clinic: Creatine Supplement Benefits
6. Frontiers in Aging Neuroscience
7. Neurotherapeutics
8. Journal of Clinical Psychopharmacology
9. European Heart Journal
10. Experimental Gerontology
11. Clinical Science
12. Diabetes Care

Creatine supplementation is generally considered safe for healthy individuals of various ages, but it is most commonly recommended for adults. Here are some guidelines and considerations for starting creatine supplementation:

General Guidelines

1. Adults:

   • Creatine supplementation is widely studied and recommended for adults, particularly those involved in high-intensity sports or resistance training. Most studies involve participants aged 18 and older.
   • For adults, the typical dosage is 3-5 grams per day, which can help improve exercise performance, muscle mass, and overall health.

2. Teenagers:

   • While creatine is also considered safe for teenagers, it is important to approach supplementation with caution. Studies suggest that teenagers aged 16 and older can safely use creatine under proper supervision and guidance, particularly if they are engaged in competitive sports or high-intensity training.
   • The International Society of Sports Nutrition (ISSN) states that creatine is safe and effective for athletes, including those in adolescence, when used at recommended doses .

3. Children:

   • Creatine supplementation for children under the age of 16 is generally not recommended unless under the supervision of a healthcare provider. There is limited research on the safety and efficacy of creatine in younger children.
   • In specific medical conditions, such as certain muscular dystrophies or metabolic disorders, creatine may be prescribed by a healthcare professional to help improve muscle function and overall quality of life.

Safety Considerations

Ensure the use of high-quality creatine supplements and adhere to recommended dosages. Overuse or poor-quality supplements can lead to adverse effects, although creatine is generally well-tolerated.

1. Hydration and Nutrition:

   • Proper hydration and a balanced diet are important when taking creatine. Adequate water intake helps mitigate potential side effects such as gastrointestinal discomfort or muscle cramping.

Conclusion

• Adults: Creatine supplementation is well-supported by research and can be beneficial for adults, particularly those engaged in high-intensity exercise.
• Teenagers: Can consider creatine under proper guidance, especially if involved in competitive sports.
• Children: Generally not recommended unless prescribed for specific medical conditions and under medical supervision.

References

1. International Society of Sports Nutrition (ISSN) Position Stand: Safety and Efficacy of Creatine Supplementation in Exercise, Sport, and Medicine
2. Mayo Clinic: Creatine Supplement Benefits
3. PubMed: Safety and efficacy of creatine supplementation in children and adolescents
4. WebMD: Creatine for Athletes

By following these guidelines and consulting with healthcare professionals, individuals can make informed decisions about starting creatine supplementation.

Yes, it is possible to consume too much creatine, which can lead to various side effects and potential health issues. Here are the key points to consider:

Recommended Dosage

1. Standard Dosage:
   • The typical maintenance dose of creatine is 3-5 grams per day, which is considered safe and effective for most individuals.
   • During the initial “loading phase,” some individuals take higher doses (e.g., 20 grams per day divided into 4 doses) for 5-7 days to saturate muscle creatine stores more quickly, followed by the maintenance dose.

Potential Side Effects of Excessive Creatine Intake

1. Gastrointestinal Distress:

   • High doses of creatine can cause stomach cramps, nausea, diarrhea, and bloating. These symptoms are more common when taking large doses at once rather than spreading them out throughout the day.

2. Water Retention and Weight Gain:

   • Creatine can cause water retention in muscle cells, leading to a temporary increase in body weight. High doses may exacerbate this effect, which can be undesirable for some individuals.

3. Muscle Cramping:

   • Although not conclusively proven, some individuals report muscle cramps when using creatine, especially at higher doses.

Long-term Use and Safety

1. Long-term Effects:

   Medical Supervision:

   • Individuals with pre-existing health conditions should consult with a healthcare provider before starting creatine supplementation.
   • • Long-term use of creatine at recommended doses (3-5 grams per day) is generally considered safe. However, the safety of high doses over extended periods is less well-studied.

Conclusion

While creatine is generally safe and beneficial when taken at recommended doses, excessive intake can lead to adverse effects. It is important to adhere to the recommended dosages and consult with a healthcare provider, especially if there are any underlying health concerns.

References

1. Journal of the International Society of Sports Nutrition
2. Mayo Clinic: Creatine Supplement Benefits
3. WebMD: Creatine Uses and Risks
4. National Institutes of Health (NIH)

Creatine supplementation is often misunderstood, particularly concerning its effects on kidney function. Here are the key points clarified based on current evidence and expert insights, including those from Jinfiniti and Professor Jin-Xiong She.

Key Points

1. Case Reports of Kidney Damage:

   • Isolated Case: There is only one well-documented case report of kidney damage in an individual who consumed very high doses of creatine. This individual took doses far exceeding the recommended amounts, which is not representative of typical usage.
   • Reference: This case is often cited in discussions about creatine safety, but it is important to note that it is an isolated incident and not reflective of the effects at recommended dosages .

2. Creatinine Levels and eGFR:

   • Increase in Creatinine: Creatine supplementation can lead to an increase in serum creatinine levels because creatine is metabolized into creatinine. This increase is a normal physiological response and not indicative of kidney damage.
   • eGFR Misinterpretation: Estimated glomerular filtration rate (eGFR) is commonly used to assess kidney function, calculated based on creatinine levels. An increase in creatinine can lower the eGFR, leading to a false impression of impaired kidney function.
   • Supporting Data: Jinfiniti and Professor Jin-Xiong She have data showing that while creatinine levels increase with creatine supplementation, other kidney biomarkers remain unchanged. This indicates that the kidneys are functioning normally despite the elevated creatinine .

3. Misinterpretation of Data:

   • Widespread Misinterpretation: The notion that creatine causes kidney issues is largely due to the misinterpretation of elevated creatinine levels. Elevated creatinine in the context of creatine supplementation reflects increased creatine metabolism rather than impaired kidney function.
   • Clarifying Publications: Leading medical institutions and publications sometimes perpetuate this misunderstanding. More nuanced interpretations, considering other kidney function markers, are necessary to avoid misleading conclusions about creatine’s safety.

Supporting Evidence

1. Studies on Healthy Individuals:

   • Research has consistently shown that creatine supplementation at recommended doses does not adversely affect kidney function in healthy individuals. Long-term studies have found no significant changes in kidney function markers.
   • References:
     • Journal of the International Society of Sports Nutrition
     • Clinical Journal of Sport Medicine

2. Expert Opinions:

   • Experts, including Professor Jin-Xiong She of Jinfiniti, emphasize that the increase in creatinine should be viewed in the context of other kidney function markers. If these markers remain stable, there is no evidence of kidney damage.
   • Supporting Data: Jinfiniti’s research supports the safety of creatine supplementation, showing no adverse effects on kidney biomarkers apart from the expected rise in creatinine.

Conclusion

Creatine supplementation, when taken at recommended doses, does not cause kidney damage. The rise in creatinine levels seen with supplementation reflects increased creatine metabolism and not compromised kidney function. Misinterpretations of these changes have led to widespread misconceptions about creatine’s safety. Comprehensive evaluations considering all kidney function markers are necessary to accurately assess the impact of creatine.

References

1. Journal of the International Society of Sports Nutrition: Creatine supplementation and kidney function
2. Clinical Journal of Sport Medicine: Long-term creatine supplementation
3. Mayo Clinic: Creatine Supplement Benefits and Risks
4. Jinfiniti Precision Medicine: Research and data on creatine and kidney biomarkers.

Creatine is generally considered safe for most people, but it can interact with certain supplements and medications. Here are some potential interactions to be aware of:

Potential Interactions with Supplements

1. Caffeine:

   • Synergistic Effects: Some studies suggest that combining creatine with caffeine can enhance performance benefits, but the evidence is mixed.
   • Possible Interference: There are indications that caffeine might interfere with the body’s ability to use creatine effectively. For instance, some research has shown that caffeine may counteract the benefits of creatine in high-intensity exercise and muscle recovery .

2. Other Stimulants:

   • Combining creatine with other stimulants (e.g., ephedrine) can increase the risk of side effects such as increased heart rate and blood pressure.

Potential Interactions with Medications

Diuretics increase urine production, which can lead to dehydration. Creatine also requires increased water intake to avoid dehydration and muscle cramping, so combining these might exacerbate dehydration risks.

Continuing with creatine supplementation depends on your personal goals and health status. If you are looking to maintain or improve muscle mass, strength, and exercise performance, ongoing creatine supplementation can be beneficial. It is also helpful for older adults to counteract age-related muscle loss and improve cognitive function. However, if you are not actively training or do not have specific health goals that benefit from creatine, you may not need to continue supplementation.

Key Points:

• Exercise and Performance: If you are engaged in high-intensity exercise or strength training, continuing creatine can help maintain muscle mass and performance .
• Aging and Muscle Health: For older adults, creatine can help reduce sarcopenia and support overall muscle health .
• Safety: Creatine is generally safe for long-term use at recommended doses .

Consult with a healthcare provider to tailor your supplementation to your individual needs and health conditions.

References:

1. Journal of the International Society of Sports Nutrition
2. Mayo Clinic: Creatine
3. PubMed: Creatine Supplementation in Older Adults
4. National Institutes of Health (NIH)