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Unraveling the Science Behind Bryan Johnson’s Pursuit to Reverse Aging

Written by Jinfiniti Email on . Posted in Aging, Biomarker Testing, Exercise and Fitness, NAD & NAD Precursors.

In recent years, there has been a growing interest in the field of aging research and the possibility of reversing the effects of aging. One prominent figure at the forefront of this pursuit is Bryan Johnson, an entrepreneur and philanthropist who has dedicated significant resources to unraveling the science behind aging. This article will delve into Johnson’s motivations, the science of aging, his approach to reversing it, and the potential implications of such a breakthrough. It will also address the challenges and criticisms associated with this field of research.

ALT TXT IMG: Hourglass

Understanding Bryan Johnson’s Motivation

Johnson’s passion for reversing aging stems from a deeply personal journey. Like many, he has witnessed the toll that aging takes on loved ones, both physically and mentally. This firsthand experience has fueled his desire to find a solution and improve the quality of life for individuals as they age.

Johnson firmly believes that aging should not be accepted as an inevitable part of life. He is driven by the conviction that we can slow down, halt, and even reverse the aging process with the right scientific advancements and interventions. But what led Johnson to this realization? How did he come to understand that aging is not an immutable process?

The Personal Journey Towards Reversing Aging

Johnson’s realization that aging is not an immutable process came after encountering scientific studies highlighting the potential for interventions to slow down or even reverse the aging process. This transformative discovery prompted him to dedicate his resources and efforts to aging research.

While exploring the scientific literature, Johnson stumbled upon groundbreaking studies that revealed the remarkable regenerative capabilities of certain organisms. He learned about the intricate mechanisms that allow these organisms to repair and rejuvenate their cells, effectively defying aging.

These findings ignited a spark within Johnson. He realized that if nature had already provided examples of organisms capable of reversing aging, then perhaps it was possible to replicate and harness these mechanisms for the benefit of human beings.

Driven by curiosity and a deep desire to make a difference, Johnson embarked on a journey of discovery. He sought out leading scientists, researchers, and experts in the field of aging to learn from their knowledge and insights. Through countless conversations and collaborations, he gained a comprehensive understanding of the biological processes underlying aging and the potential avenues for intervention.

The Role of Entrepreneurship in Aging Research

As an entrepreneur, Johnson believes in the power of innovation to drive progress. He recognizes that the aging process is a complex biological phenomenon, requiring multidisciplinary approaches to understand and address it fully. By exploring aging through an entrepreneurial lens, he aims to bring together experts from various fields to accelerate the development of breakthrough technologies.

Johnson understands that the pursuit of reversing aging requires not only scientific expertise but also a strategic and entrepreneurial mindset. He believes that by fostering collaboration between scientists, engineers, and entrepreneurs, we can expedite the translation of scientific discoveries into practical solutions.

Johnson has established research initiatives and partnerships with leading institutions and organizations through his entrepreneurial endeavors. He has provided funding and resources to support innovative projects that aim to unravel the mysteries of aging and develop interventions that can extend human healthspan.

His entrepreneurial approach to aging research is rooted in the belief that combining scientific rigor with business acumen can create a future where aging is no longer a barrier to a fulfilling and vibrant life.

The Science of Aging: A Brief Overview

To comprehend Johnson’s pursuit, you must first grasp the underlying biological processes of aging. Aging is a multifaceted phenomenon involving many interconnected factors, including genetic, epigenetic, and environmental influences.

Understanding the science behind aging is crucial in unraveling the mysteries of this complex process. It is at the cellular and systemic levels that aging manifests its effects. At the cellular level, various factors contribute to the gradual decline in function and vitality. One such factor is accumulated DNA damage, which occurs over time due to exposure to environmental toxins, radiation, and normal metabolic processes. This damage can lead to mutations and impair the cell’s ability to function optimally.

Another cellular process that contributes to aging is telomere shortening. Telomeres are protective caps at the ends of chromosomes that gradually shorten with each cell division. As telomeres shorten, cells become more susceptible to DNA damage and eventually reach a point where they can no longer divide, leading to cellular senescence.

In addition to DNA damage and telomere shortening, mitochondrial dysfunction also plays a role in aging. Mitochondria are the cell’s powerhouses responsible for producing energy in the form of ATP. However, as you age, mitochondrial function declines, leading to decreased energy production and increased oxidative stress. This oxidative stress can further damage DNA and other cellular components, contributing to aging.

At the systemic level, aging involves the decline in organ function and the deterioration of the immune system. As you age, organs such as the heart, lungs, and kidneys gradually lose their ability to function optimally. This decline in organ function can lead to a variety of age-related diseases, such as cardiovascular disease, respiratory disorders, and kidney failure.

The immune system also changes with age, a process known as immunosenescence. As the immune system weakens, older individuals become more susceptible to infections, autoimmune diseases, and cancer. This decline in immune function is attributed to a combination of factors, including changes in the composition of immune cells, decreased production of immune cells, and impaired immune response.

ALT TXT IMG: Exercise

The Current State of Aging Research

Aging research has made significant strides in recent years, uncovering potential interventions that may slow down or reverse the aging process. Scientists and researchers worldwide are dedicated to understanding aging mechanisms and developing strategies to promote healthy aging.

One area of research that has gained considerable attention is genetic manipulations. By studying the genes that regulate aging, scientists have identified specific genetic pathways that influence lifespan and healthspan. Manipulating these pathways in model organisms, such as worms, flies, and mice, has shown promising results in extending lifespan and delaying age-related diseases.

Another avenue of research is focused on pharmaceutical interventions. Scientists are exploring various compounds and drugs that can potentially target specific aging pathways and promote healthy aging. These interventions aim to mitigate the effects of age-related cellular and systemic damage, ultimately improving overall health and extending lifespan.

Furthermore, lifestyle factors such as diet and exercise have also been shown to influence the aging process. A healthy diet rich in antioxidants, vitamins, and minerals can help reduce oxidative stress and inflammation, both of which contribute to aging. Regular physical activity has also been associated with improved cardiovascular health, increased muscle mass, and enhanced cognitive function in older adults.

In conclusion, the science of aging is a complex and fascinating field of study. By delving into the biological processes of aging at the cellular and systemic levels, researchers are gaining insights into the mechanisms that drive this natural phenomenon. With ongoing research and advancements in technology, scientists hope to unravel the secrets of aging and develop interventions that enable individuals to live longer, healthier lives.

Bryan Johnson’s Approach to Reversing Aging

Regarding reversing aging, Bryan Johnson has a unique approach that revolves around the intersection of technology and biology. He firmly believes that innovative technologies, such as neural interfaces, hold the key to unlocking the secrets of aging and developing effective interventions.

But what exactly does this intersection of technology and biology entail? 

The Intersection of Technology and Biology

Technological advancements have revolutionized the field of biology. With the advent of artificial intelligence and machine learning, scientists now have the tools to analyze biological data on an unprecedented scale. This allows them to unravel the aging process’s intricacies and identify potential intervention targets.

Researchers can delve into the molecular mechanisms underlying aging by utilizing these cutting-edge technologies. They can study the genetic factors contributing to aging and identify ways to manipulate them. This deeper understanding of the biology of aging opens up new avenues for developing interventions that can slow down or even reverse the aging process.

The Importance of Neural Interfaces

One of the key components of Bryan Johnson’s approach is the use of neural interfaces. These interfaces, which allow direct communication between the brain and external devices, hold immense promise in aging research.

Neural interfaces have already shown great potential in various fields, such as restoring movement to paralyzed individuals or helping people with neurodegenerative diseases regain their independence. But their potential goes beyond that.

By harnessing the power of neural interfaces, scientists hope to enhance cognitive functioning in aging individuals. During aging, cognitive decline becomes a common occurrence, affecting memory, attention, and overall mental sharpness. Neural interfaces could potentially help reverse or mitigate these age-related cognitive impairments.

Furthermore, neural interfaces could also play a crucial role in tackling neurodegenerative diseases, such as Alzheimer’s or Parkinson’s. The progressive loss of neurons and cognitive decline characterize these conditions. By establishing direct communication between the brain and external devices, neural interfaces could potentially slow down or even halt the progression of these devastating diseases.

In conclusion, Bryan Johnson’s approach to reversing aging is a fascinating blend of technology and biology. By leveraging technological advancements and exploring the potential of neural interfaces, he aims to unlock the secrets of aging and develop effective interventions. The intersection of technology and biology offers a promising path towards a future where aging is no longer an inevitable process but a condition that can be managed and even reversed.

The Potential Implications of Reversing Aging

The implications of reversing aging are far-reaching and have sparked lively debates within the scientific community and society at large.

Ethical Considerations and Debates

The prospect of extending the human lifespan raises ethical questions surrounding the distribution of resources, overpopulation concerns, and the potential impact on societal dynamics. Engaging in thoughtful discussions to address these ethical challenges and ensure equitable access to any potential breakthroughs is crucial.

The Future of Human Longevity

Reversing aging has the potential to redefine the concept of human longevity. It could enhance both the quantity and quality of years, allowing individuals to lead fulfilling lives for extended periods. It may also redefine traditional life stages and fundamentally impact healthcare, retirement, and societal structures.

The Challenges and Criticisms

While the pursuit of reversing aging holds immense promise, it is not without its challenges and critics.

The Skepticism Surrounding Anti-Aging Research

Some skeptics question the feasibility of reversing aging, arguing that the complexity of the aging process necessitates a more nuanced approach. They emphasize the need for continued research and caution against premature claims.

The Hurdles in Translating Science into Practice

Translating scientific discoveries into tangible interventions poses a significant challenge. The gap between laboratory findings and real-world applications is vast, requiring rigorous testing, regulatory approvals, and substantial investments. However, Johnson remains steadfast in his commitment to bridging this gap and transforming scientific breakthroughs into practical solutions.

In conclusion, Bryan Johnson’s pursuit to reverse aging can revolutionize one’s understanding of human longevity and transform how aging is approached. While many challenges and skeptics remain, Johnson’s dedication and multidisciplinary approach offer hope for a future where aging is no longer an inevitable decline but rather a reversible process. As the field continues to advance, it is crucial to maintain a robust dialogue and consider the ethical implications to ensure that any breakthroughs are utilized responsibly for the benefit of all. Begin your pursuit to reverse aging with the AgingSOS® Starter Panel to test your longevity biomarker panels. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Why Optimized, Precision Medicine is the Future

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code Blog15 if you’re a new customer for 15% off your 1st order).

Understanding Senescence: The Science of Aging and Cellular Degeneration

Written by Jinfiniti Email on . Posted in Aging, Exercise and Fitness, NAD & NAD Precursors.

Senescence, the natural aging process, is a complex phenomenon affecting all living organisms. Cells and tissues undergo degenerative changes when the body ages, leading to decreased physiological function. To comprehend the mechanisms behind senescence, it is crucial to delve into the biological basis of aging and understand the intricate processes contributing to cellular degeneration.

ALT TXT IMG: Red blood cells

The Biological Basis of Aging

The Role of DNA in Aging

One of the key factors contributing to cellular aging is the gradual accumulation of DNA damage. Over time, exposure to environmental factors such as radiation and toxins can cause mutations in the DNA sequence. These mutations disrupt normal cellular processes and lead to the deterioration of various tissues and organs.

When looking deeper into the role of DNA in aging. DNA, or deoxyribonucleic acid, is the genetic material that carries the instructions for the development and functioning of all living organisms. It is composed of nucleotides, which are the building blocks of DNA. These nucleotides consist of a sugar molecule, a phosphate group, and one of four nitrogenous bases: adenine (A), thymine (T), cytosine (C), and guanine (G).

When DNA is damaged, it can lead to a variety of consequences. For example, a mutation in a specific gene may produce a faulty protein, which can disrupt normal cellular processes. DNA damage can also lead to chromosomal abnormalities, such as deletions, insertions, or translocations, which can profoundly affect cell function.

It is worth noting that the human body has evolved various mechanisms to repair DNA damage. These repair mechanisms, such as base excision repair and nucleotide excision repair, help maintain the integrity of the genome. However, during aging, the efficiency of these repair processes tends to decline, leading to an accumulation of DNA damage.

Cellular Degeneration: An Inevitable Process?

Scientists have long debated whether cellular degeneration is an inevitable consequence of aging or if it can be delayed or prevented. It is now believed that while certain aspects of senescence are inevitable, lifestyle factors and genetic predisposition can influence the rate at which degenerative changes occur.

Senescence refers to cellular function’s gradual deterioration and replicative capacity loss. It is a complex process involving various molecular and cellular changes. One of the hallmarks of senescence is the shortening of telomeres, which are protective caps at the ends of chromosomes. Telomeres naturally shorten with each cell division, eventually reaching a critical length that triggers cellular senescence.

However, lifestyle factors such as diet, exercise, and stress management can impact the rate of telomere shortening. For example, a healthy diet rich in antioxidants and nutrients can help protect telomeres from oxidative damage. Regular physical activity has also been shown to positively affect telomere length, potentially slowing down the aging process.

Furthermore, genetic factors play a role in determining an individual’s susceptibility to cellular degeneration. Certain genetic variations can affect the efficiency of DNA repair mechanisms or the stability of telomeres, making some individuals more prone to age-related cellular damage.

By understanding the stages of cellular aging and the impact of senescence on organ function, scientists and researchers can explore potential strategies to slow down the aging process. This knowledge can pave the way for developing interventions and therapies to promote healthy aging and extend the lifespan.

The Process of Senescence

The process of senescence, or cellular aging, is a complex phenomenon that involves various stages and impacts the overall function of organs and systems within the body. Understanding the different stages of cellular aging and its effects on organ function is crucial in comprehending the aging process.

The Stages of Cellular Aging

Cellular aging can be broadly categorized into three stages: replicative, chronological, and stress-induced senescence. Each stage represents a different mechanism through which cells undergo aging.

Replicative senescence occurs when cells reach their maximum replicative capacity and can no longer divide. This stage is characterized by the shortening of telomeres, and protective caps at the ends of chromosomes. As telomeres progressively shorten with each cell division, they eventually reach a critical length, triggering replicative senescence. This phenomenon is often referred to as the “Hayflick limit,” named after Leonard Hayflick, who first observed this phenomenon in human cells.

Chronological senescence, on the other hand, is the result of the accumulation of damage over time. As cells are exposed to various environmental factors and undergo metabolic processes, they accumulate DNA damage, protein misfolding, and other forms of cellular damage. Over time, this damage exceeds the cell’s repair capacity, leading to a decline in cellular function and ultimately contributing to aging.

Lastly, various stressors, such as oxidative stress or DNA damage, trigger stress-induced senescence. When cells are exposed to excessive levels of reactive oxygen species (ROS) or encounter DNA damage, they activate specific signaling pathways that induce senescence. This stress response aims to prevent the proliferation of damaged cells and maintain tissue integrity. However, chronic exposure to stressors can lead to an accumulation of senescent cells, which can harm organ function.

The Impact of Senescence on Organ Function

Senescence not only affects individual cells but also profoundly impacts the function of organs and systems within the body. The aging process can significantly impair the function of various organs, leading to an increased risk of age-related diseases.

For example, aging can significantly impair cardiovascular function, leading to an increased risk of heart disease and hypertension. As the heart ages, it undergoes structural and functional changes, such as the thickening of the heart muscle and decreased elasticity of blood vessels. 

These changes can result in reduced cardiac output, impaired blood flow, and an increased workload on the heart, ultimately contributing to the development of cardiovascular diseases.

Similarly, the nervous system can undergo age-related changes, resulting in cognitive decline and an increased susceptibility to neurological disorders. As individuals age, they may experience a decline in memory, attention, and cognitive processing speed. 

These changes are attributed to various factors, including the accumulation of cellular damage, reduced neuroplasticity, and alterations in neurotransmitter systems. Age-related neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease, are also associated with the progressive loss of neuronal function and the accumulation of senescent cells in the brain.

In addition to cardiovascular and neurological effects, senescence can also impact other organ systems. The musculoskeletal system undergoes age-related changes, including the loss of muscle mass and strength, decreased bone density, and impaired joint function. The immune system also undergoes alterations with age, leading to a decline in immune function and an increased susceptibility to infections and autoimmune diseases.

Overall, senescence is a complex process involving multiple stages of cellular aging and profoundly impacts organ function. Understanding the mechanisms and consequences of senescence is crucial in developing strategies to promote healthy aging and prevent age-related diseases.

ALT TXT IMG: Lab testing

Theories of Aging and Senescence

As our understanding of the complex aging process continues to evolve, several theories have emerged to explain why and how our bodies age. These theories provide valuable insights into the mechanisms underlying the gradual deterioration of cells and tissues over time. Two prominent theories, the Free Radical Theory, and the Telomere Theory, shed light on different aspects of the aging process.

The Free Radical Theory

The Free Radical Theory proposes that the accumulation of oxidative damage primarily causes aging. Free radicals, unstable molecules that result from normal metabolic processes, can cause significant damage to cellular structures such as proteins, lipids, and DNA. These highly reactive molecules can potentially disrupt the delicate balance within cells, leading to the gradual deterioration of tissues and organs.

When free radicals interact with cellular components, they can initiate a chain reaction of damage, impairing the normal functioning of cells. This theory suggests that an imbalance between free radicals and antioxidant defenses, which neutralize these harmful molecules, leads to the accumulation of oxidative damage over time. As the body’s antioxidant defenses become less effective with age, the damage caused by free radicals becomes more pronounced, contributing to aging.

While the Free Radical Theory provides valuable insights into the role of oxidative stress in aging, it is important to note that other factors, such as genetic predisposition and environmental influences, also play significant roles in the complex process of aging.

The Telomere Theory

Another prominent theory of aging is the Telomere Theory, which focuses on the role of telomeres in determining the lifespan of cells. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division. These repetitive DNA sequences act as a buffer, preventing the loss of essential genetic material during replication.

According to the Telomere Theory, as cells divide, their telomeres gradually shorten. Once telomeres reach a critically short length, cells enter a state of replicative senescence, where they can no longer divide and function properly. This theory suggests that telomere shortening acts as a clock, determining the lifespan of cells and contributing to overall aging.

While telomere shortening is a natural and inevitable process, it can be influenced by various factors, including lifestyle choices and environmental factors. Chronic stress, poor nutrition, and exposure to harmful substances can accelerate telomere shortening, leading to premature aging.

Understanding the mechanisms underlying telomere shortening and its impact on aging is a topic of ongoing research. Scientists are exploring potential interventions, such as telomerase activation, to prevent or reverse telomere shortening and potentially slow down the aging process.

It is important to note that the Free Radical Theory and the Telomere Theory are not mutually exclusive. In fact, these theories complement each other, providing a more comprehensive understanding of the complex process of aging. Further research is needed to unravel the intricate interplay between these theories and uncover additional factors contributing to the aging process.

The Physiological Effects of Aging

Aging and the Cardiovascular System

Structural and functional changes in the heart and blood vessels characterize cardiovascular aging. When aging, blood vessels become stiffer and less elastic, leading to increased blood pressure and reduced circulation. Additionally, age-related changes in the heart can result in impaired cardiac function and an increased risk of heart disease.

Aging and the Nervous System

The nervous system is also profoundly affected by aging. Neurons gradually decline in number and undergo structural changes, affecting cognitive function and memory. Age-related neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, can further exacerbate these changes and lead to severe impairments in motor and cognitive abilities.

The Molecular Mechanisms of Senescence

Autophagy and Senescence

Autophagy, the process by which cells recycle damaged or dysfunctional components, plays a critical role in senescence. Impaired autophagy can lead to the accumulation of toxic cellular waste and accelerate the aging process. Understanding the molecular mechanisms that regulate autophagy may offer insights into potential therapeutic strategies to counteract senescence.

Senescence-Associated Secretory Phenotype (SASP)

SASP refers to senescent cells’ production and release of various molecules, including pro-inflammatory cytokines, growth factors, and matrix metalloproteinases. SASP can have both beneficial and detrimental effects. While it helps eliminate damaged cells and promote tissue repair, chronic SASP activation can contribute to age-related chronic inflammation and tissue dysfunction.

Conclusion

Senescence, the natural aging process, and cellular degeneration, is a complex phenomenon involving various biological, molecular, and physiological changes. By unraveling the mechanisms behind senescence, scientists can gain valuable insights into potential interventions to slow the aging process and improve health outcomes. With further research, scientists may be able to unlock the secrets of a longer and healthier lifespan. Take the AgingSOS® test by Jinfiniti Precision Medicine, Inc. to assess your level of cellular health. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. 9 Powerful Benefits of Optimizing Your NAD
  2. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity
  3. What Does Peak Performance Look Like? 
  4. Why Optimized, Precision Medicine is the Future

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code Blog15 if you’re a new customer for 15% off your 1st order).

The Role and Benefits of NAD Supplements in Cellular Health

Written by Jinfiniti Email on . Posted in Aging, Fatigue, NAD & NAD Precursors.

In recent years, there has been increasing interest in NAD supplements and their potential benefits for cellular health. NAD, which stands for Nicotinamide Adenine Dinucleotide, is a coenzyme found in every cell of our bodies. It plays a crucial role in various biological processes, including energy production, DNA repair, and regulation of cellular aging.

ALT TXT IMG: NAD+ biosynthesis pathway

Understanding NAD Supplements

What are NAD Supplements?

NAD supplements are dietary supplements that aim to support and enhance the levels of NAD in the body. These supplements typically contain compounds, such as nicotinamide riboside (NR) or NAD+ precursor, which can be converted into NAD once ingested.

The Biological Role of NAD

NAD is involved in hundreds of enzymatic reactions in the body and is essential for the proper functioning of various physiological processes. One of its primary roles is participating in cellular energy production through processes like glycolysis and the citric acid cycle. NAD serves as a coenzyme for enzymes involved in these pathways, allowing them to facilitate the production of ATP, the energy currency of cells.

Beyond its energy-related functions, NAD also plays a critical role in DNA repair. It is a cofactor for enzymes known as sirtuins, which are involved in DNA damage repair and maintenance of genomic stability. By facilitating DNA repair, NAD helps to protect the integrity of genetic material and prevent the accumulation of mutations.

Moreover, NAD is involved in regulating various aspects of cellular metabolism. It acts as a signaling molecule, influencing the activity of proteins involved in processes like gene expression, cell survival, and stress response. NAD-dependent signaling pathways are crucial in maintaining cellular homeostasis and adapting to environmental changes.

Furthermore, NAD is closely linked to the aging process. As you age, the levels of NAD in your body naturally decline, leading to a decline in cellular function and an increased risk of age-related diseases. By supplementing with NAD precursors like NR or NAD+ precursor, you are believed to replenish NAD levels and potentially slow down the aging process.

“Only 20 percent of our longevity is genetically determined. The rest is what we do, how we live our lives and increasingly the molecules that we take. It’s not the loss of our DNA that causes aging, it’s the problems in reading the information, the epigenetic noise.” – Dr. David Sinclair, Leading Anti-Aging Researcher, Professor at Harvard Medical & Author of Lifespan

Research in animal models has shown promising results, with NAD supplementation demonstrating potential benefits for various age-related conditions, including neurodegenerative diseases, cardiovascular diseases, and metabolic disorders. However, more research is needed to fully understand the effects of NAD supplements in humans and their long-term safety.

In conclusion, NAD supplements are dietary supplements that aim to support and enhance the levels of NAD in the body. NAD is crucial in cellular energy production, DNA repair, and cellular metabolism. By supplementing with NAD precursors, it is believed that you can potentially slow down the aging process and improve overall health. 

The Connection Between NAD and Cellular Health

When it comes to maintaining optimal cellular health, one must recognize the crucial role played by NAD. NAD, short for Nicotinamide Adenine Dinucleotide, is a coenzyme that is present in all living cells. It is involved in many cellular processes, making it a key player in overall cellular function.

NAD and Cellular Energy Production

Energy production is essential for the proper function of all cells in the body. NAD acts as a key player in the production of ATP, the energy molecule that fuels various cellular processes. By supporting NAD levels, NAD supplements have the potential to enhance cellular energy production, leading to improved overall cellular health and function.

When NAD levels are optimal, cells can efficiently convert nutrients into ATP through a process called cellular respiration. This process occurs in the mitochondria, often referred to as the powerhouse of the cell. NAD is a crucial component of the electron transport chain, a series of reactions that generate ATP. By ensuring an adequate supply of NAD, cells can produce energy more efficiently, allowing them to carry out their functions effectively.

Furthermore, NAD also plays a role in regulating the activity of enzymes involved in glycolysis, the initial step in energy production. By modulating these enzymes’ activity, NAD helps maintain a balanced energy metabolism, ensuring that cells have the energy they need to perform their tasks optimally.

NAD’s Role in DNA Repair

DNA damage is an ongoing process that occurs due to various factors, including environmental stressors, metabolic byproducts, and natural aging. DNA damage can accumulate without proper repair mechanisms and lead to detrimental effects on cellular health. This is where NAD comes into play.

NAD is vital for maintaining the activity of sirtuins, a class of proteins that play a crucial role in repairing DNA damage and preserving genomic stability. Sirtuins are involved in a process called DNA repair, where they identify and correct errors in the DNA sequence. By supporting DNA repair mechanisms, NAD supplements have the potential to promote healthy cell function and slow down the aging process.

Moreover, NAD also influences the activity of other enzymes involved in DNA repair, such as PARPs (Poly ADP-ribose polymerases). These enzymes use NAD as a substrate to attach ADP-ribose units to proteins, facilitating the repair of DNA damage. By providing an ample supply of NAD, cells can ensure that these repair processes can occur efficiently, maintaining the integrity of the genetic material.

Additionally, NAD’s involvement in DNA repair extends beyond its direct role in enzymatic reactions. Studies have shown that NAD levels can influence gene expression in DNA repair pathways. By modulating gene expression, NAD can regulate the overall efficiency of DNA repair mechanisms, further contributing to cellular health.

In conclusion, NAD plays a vital role in cellular energy production and DNA repair, two essential processes for maintaining optimal cellular health. By supporting NAD levels through supplementation, individuals can potentially enhance their cellular energy production and promote healthy DNA repair mechanisms. This, in turn, can positively impact overall cellular function and contribute to improved health and well-being.

ALT TXT IMG: DNA Strings

The Potential Benefits of NAD Supplements

NAD supplements have gained significant attention in recent years due to their potential benefits in various aspects of health and well-being. Here are some of the ways in which NAD supplements may contribute to enhancing cellular longevity and boosting metabolic health.

Enhancing Cellular Longevity

Cellular aging is a complex process influenced by various factors, including oxidative stress, DNA damage, and declining mitochondrial function. As you age, your cells become more susceptible to these age-related processes, leading to a decline in overall cellular health.

However, NAD supplements have been proposed as a potential strategy to combat these age-related processes. NAD, or nicotinamide adenine dinucleotide, is a coenzyme involved in cellular energy production and DNA repair mechanisms.

By supporting energy production, NAD supplements may help cells maintain their optimal function and vitality. Additionally, NAD is crucial for DNA repair and essential for maintaining your genetic material’s integrity. By enhancing DNA repair mechanisms, NAD supplements may contribute to overall cellular health and longevity.

Furthermore, NAD supplements have been shown to activate sirtuins, a group of proteins involved in regulating cellular processes such as metabolism, inflammation, and stress response. Activation of sirtuins has been linked to increased lifespan and improved healthspan in various organisms.

Therefore, by enhancing cellular health and longevity, NAD supplements hold promise as a potential strategy for promoting healthy aging and overall well-being.

Boosting Metabolic Health

Metabolism is crucial in maintaining a healthy weight and preventing metabolic disorders such as diabetes and obesity. NAD, as a key player in cellular metabolism, is involved in regulating metabolic pathways.

One of the essential roles of NAD in metabolism is its involvement in the breakdown of carbohydrates, fats, and proteins. By supporting NAD levels, NAD supplements have the potential to optimize metabolic function and promote overall metabolic health.

Furthermore, NAD is involved in regulating insulin secretion and sensitivity, which are critical factors in maintaining healthy blood sugar levels. By supporting NAD levels, NAD supplements may help regulate insulin function and contribute to improved glucose metabolism.

Moreover, NAD has been shown to activate enzymes involved in mitochondrial biogenesis, the process of forming new mitochondria. Mitochondria are the powerhouses of cells and are responsible for energy production. NAD supplements may enhance cellular energy production and overall metabolic function by promoting mitochondrial biogenesis.

Overall, NAD supplements hold promise as a potential strategy for boosting metabolic health and optimizing various aspects of metabolism, including carbohydrate, fat, and protein metabolism, insulin function, and mitochondrial biogenesis.

Safety and Efficacy of NAD Supplements

When considering NAD supplements, following the recommended dosage guidelines provided by the manufacturer or healthcare professional is essential. Dosage recommendations may vary depending on the specific NAD precursor compound used and individual factors such as age and health status. It is always advisable to consult with a healthcare professional before starting any new supplement regimen.

NAD, or nicotinamide adenine dinucleotide, is a coenzyme found in all living cells. It is crucial in various biological processes, including energy production, DNA repair, and cellular communication. Research suggests that NAD supplementation may have several potential benefits. It has been shown to support mitochondrial function, which produces energy in our cells. NAD supplements may help improve overall energy levels and combat fatigue by enhancing mitochondrial function.

In addition to its role in energy production, NAD is involved in DNA repair mechanisms. By promoting DNA repair, NAD supplements may help protect against DNA damage caused by factors such as oxidative stress and aging. This potential benefit has sparked interest in NAD supplementation for its potential anti-aging effects.

Furthermore, NAD is a key regulator of sirtuins, a family of proteins involved in various cellular processes, including gene expression, inflammation, and metabolism. By activating sirtuins, NAD supplements may help regulate these processes and potentially contribute to improved overall health and longevity.

Potential Side Effects and Precautions

While NAD supplements are generally considered safe for most people, it is essential to be aware of potential side effects and precautions. Some individuals may experience mild digestive issues, such as nausea or diarrhea when first starting NAD supplements. These symptoms are usually temporary and subside as the body adjusts to the supplement.

It is also important to note that NAD supplements should not be used as a substitute for a healthy lifestyle or medical treatment. They should be seen as a complementary approach to overall well-being. If you have any underlying medical conditions or are taking medications, it is crucial to consult with your healthcare professional before incorporating NAD supplements into your routine.

Additionally, as with any supplement, it is crucial to source NAD supplements from reputable manufacturers like Jinfiniti Precision Medicine, Inc. to ensure product quality and safety. Look for products that have undergone third-party testing and are certified by reputable organizations. This will help ensure that you are getting a reliable and effective product.

In conclusion, NAD supplements have gained attention for their potential benefits in supporting energy production, DNA repair, and overall cellular health. However, it is important to follow the recommended dosage guidelines and consult with a healthcare professional before starting any new supplement regimen. By being aware of potential side effects and precautions and sourcing NAD supplements from reputable manufacturers, you can make informed decisions about incorporating them into your wellness routine.

The Future of NAD Supplements in Health and Wellness

Ongoing Research and Development

The field of NAD research is constantly evolving, with ongoing studies exploring new aspects of NAD’s functions and potential benefits. Scientists are continuing to investigate the impact of NAD supplementation on various health conditions, including age-related diseases, neurodegenerative disorders, and metabolic disorders. This ongoing research holds promising prospects for the future of NAD supplements and their role in promoting health and wellness.

NAD Supplements and Personalized Medicine

As an understanding of NAD’s role in cellular health and disease advances, the field of personalized medicine may benefit from incorporating NAD measurements and interventions. By assessing an individual’s NAD levels and tailoring supplement recommendations accordingly, healthcare professionals may be able to optimize health outcomes and mitigate disease risks on an individualized basis.

In conclusion, NAD supplements have emerged as an exciting research area in cellular health. By supporting NAD levels, these supplements have the potential to enhance cellular energy production, promote DNA repair mechanisms, and ultimately contribute to overall health and well-being. However, it is important to consult with a healthcare professional before starting any new supplement regimen to ensure safety and suitability for individual needs. As ongoing research continues to shed light on NAD’s functions and potential benefits, the future of NAD supplements in health and wellness holds promising prospects. Are you deficient in NAD? Measure your NAD levels with the Intracellular NAD® Test. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity
  3. What Does Peak Performance Look Like? 
  4. 9 Powerful Benefits of Optimizing Your NAD

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code Blog15 if you’re a new customer for 15% off your 1st order).

Unraveling the Mystery: Understanding What NAD Is and Its Importance

Written by Jinfiniti Email on . Posted in Aging, NAD & NAD Precursors.

Nicotinamide adenine dinucleotide, commonly known as NAD, is a coenzyme found in all living cells. Its importance lies in its role as a critical component in several essential biological processes. By unraveling the mystery surrounding NAD, you can gain valuable insights into its functions and understand its significance for overall health and well-being.

Decoding the Acronym: What is NAD?

At its most basic definition, NAD is a molecule that participates in numerous enzymatic reactions within cells. It acts as a coenzyme, meaning it assists enzymes in facilitating chemical reactions. In simple terms, NAD is involved in cellular metabolism, playing a crucial role in energy production and DNA repair.

The Basic Definition of NAD

NAD is a dinucleotide, meaning it consists of two nucleotides joined by a phosphate group. The nucleotides in NAD can be either adenine and ribose (forming NAD+) or nicotinamide and ribose (forming NADH). The “+” or “H” symbolizes the oxidized or reduced state of NAD, respectively.

The Scientific Explanation of NAD

From a scientific perspective, NAD’s significance lies in its ability to act as an electron carrier during redox reactions. In these reactions, NAD accepts and donates electrons, which are crucial for energy transfer within cells.

Moreover, NAD’s involvement in the redox reactions is essential for the conversion of food into energy. It helps break down carbohydrates, fats, and proteins, enabling cells to produce ATP (adenosine triphosphate), the energy currency of the body.

It is important to understand the role of NAD in cellular metabolism. One of the critical functions of NAD is its involvement in glycolysis, the initial step in the breakdown of glucose. During glycolysis, glucose is converted into pyruvate, generating a small amount of ATP and reducing NAD+ to NADH.

But NAD’s role doesn’t stop there. NADH, the reduced form of NAD, carries the high-energy electrons extracted from glucose to the electron transport chain (ETC) in the mitochondria. The ETC is a protein complex series that transfers electrons and generates a proton gradient across the inner mitochondrial membrane.

As the electrons move through the ETC, energy is released and used to pump protons across the membrane. This creates a proton gradient, which drives the synthesis of ATP through a process called oxidative phosphorylation. NADH plays a crucial role in this process by donating its electrons to the ETC, ultimately leading to the production of ATP.

In addition to its role in energy production, NAD is also involved in DNA repair. When DNA is damaged, enzymes called poly(ADP-ribose) polymerases (PARPs) utilize NAD+ to add ADP-ribose units to proteins, including histones and DNA repair enzymes. This process, known as ADP-ribosylation, helps recruit and activate DNA repair machinery, ensuring the integrity of the genome.

Furthermore, NAD is important for cellular metabolism and DNA repair and plays a role in regulating various cellular processes. It acts as a signaling molecule, influencing gene expression, cell survival, and aging. NAD-dependent enzymes, such as sirtuins, are involved in regulating cellular processes like DNA repair, metabolism, and stress response.

In conclusion, NAD is a versatile molecule that plays a critical role in cellular metabolism, energy production, DNA repair, and cellular signaling. Its involvement in redox reactions, glycolysis, electron transport chain, and ADP-ribosylation highlights its significance in maintaining cellular homeostasis and overall organismal health.

The Role of NAD in the Human Body

NAD (Nicotinamide Adenine Dinucleotide) is a crucial molecule involved in various cellular functions that are vital for the proper functioning of the human body. It plays a fundamental role in maintaining cellular health, regulating metabolism, and supporting overall well-being.

NAD and Cellular Function

Within cells, NAD plays a critical role in regulating cellular processes, such as DNA repair, cell signaling, and gene expression. It acts as a coenzyme for enzymes involved in these processes, ensuring their proper functioning.

One of the key functions of NAD is its involvement in DNA repair mechanisms. DNA damage can occur due to various factors such as exposure to radiation, environmental toxins, or normal cellular processes. NAD helps activate enzymes called PARPs (Poly ADP-ribose polymerases), which are crucial in repairing damaged DNA strands. This repair process is essential for maintaining genomic stability and preventing the accumulation of mutations that could lead to diseases like cancer.

Besides DNA repair, NAD is also involved in maintaining the health and stability of the mitochondria, the powerhouses of the cell. It assists in the production of ATP (Adenosine Triphosphate), the main energy currency of the cell, through a process called oxidative phosphorylation. NAD is a key player in the electron transport chain, which generates ATP by transferring electrons from NADH to oxygen. This process ensures a steady supply of energy for cellular activities and helps prevent oxidative damage, thus promoting overall cellular health.

NAD’s Impact on Metabolism

NAD’s importance in metabolism cannot be overstated. It acts as a key regulator of metabolic pathways, influencing processes such as glycolysis, the Krebs cycle, and fatty acid oxidation. By facilitating these processes, NAD helps extract energy from nutrients and ensures a smooth metabolic flow within cells.

One of the critical roles of NAD in metabolism is its involvement in glycolysis, the initial step of glucose metabolism. NAD serves as a coenzyme for enzymes involved in glycolysis, allowing the breakdown of glucose into pyruvate and generating ATP. This process is essential for providing energy to cells, especially when oxygen availability is limited, such as during intense exercise or in certain disease conditions.

In addition to its role in glycolysis, NAD is also involved in the Krebs cycle, known as the citric acid or tricarboxylic acid cycle. This cycle is a central hub for the oxidation of various fuel molecules, including glucose, fatty acids, and amino acids. NAD acts as a coenzyme for several enzymes in the Krebs cycle, facilitating the transfer of electrons and the production of high-energy molecules like NADH and FADH2. These molecules are then used in the electron transport chain to generate ATP, providing the energy needed for cellular processes.

Furthermore, NAD regulates the balance between anabolic and catabolic processes. Anabolic processes involve synthesizing complex molecules from simpler ones, while catabolic processes involve breaking complex molecules into simpler ones. NAD participates in both types of processes, ensuring efficient utilization of nutrients and preventing metabolic imbalances. It helps regulate the activity of enzymes involved in anabolic and catabolic pathways, maintaining metabolic homeostasis and supporting overall health.

In conclusion, NAD is a multifaceted molecule that is crucial in various cellular functions and metabolic processes. Its involvement in DNA repair, cellular signaling, energy production, and metabolic regulation highlights its significance in maintaining cellular health and overall well-being. Understanding the role of NAD in the human body provides valuable insights into the intricate mechanisms that govern our biological systems.

The Importance of NAD for Health

Maintaining optimal NAD levels is crucial for overall health and well-being. NAD, short for Nicotinamide Adenine Dinucleotide, is a coenzyme found in all living cells. It is vital in various biological processes, including energy production, DNA repair, and cellular signaling.

As we age, our NAD levels tend to decline. This decline is associated with various age-related conditions, including reduced energy production, impaired cellular function, and increased disease susceptibility. The decline in NAD levels is thought to contribute to the aging process itself.

However, by maintaining adequate NAD levels, it is possible to support healthy aging and promote longevity. NAD supplementation and lifestyle interventions can potentially help counteract age-related NAD depletion.

NAD and Aging

“The loss of NAD as we age, and the resulting decline in sirtuin activity, is thought to be a primary reason our bodies develop diseases when we are old, but not when we are young.” – Dr. David Sinclair, Harvard Medical School, Lifespan

Research has shown that NAD levels tend to decline with age. This decline is associated with various age-related conditions, including reduced energy production, impaired cellular function, and increased disease susceptibility.

One of the key factors contributing to the decline in NAD levels is the activity of an enzyme called CD38. CD38 breaks down NAD into its constituent parts, leading to a decrease in NAD availability. Other factors, such as oxidative stress, inflammation, and mitochondrial dysfunction, can also contribute to NAD depletion.

By maintaining optimal NAD levels, it is possible to support healthy aging. NAD is involved in several critical processes that decline with age, including DNA repair, cellular metabolism, and mitochondrial function. Replenishing NAD levels may slow aging and reduce the risk of age-related diseases.

Furthermore, NAD is involved in the regulation of sirtuins, a family of proteins that play a crucial role in cellular health and longevity. Sirtuins are involved in various processes, including DNA repair, gene expression, and stress response. By maintaining adequate NAD levels, it is possible to support the activity of sirtuins and promote healthy aging.

NAD and Disease Prevention

Emerging studies suggest that NAD plays a role in disease prevention by regulating various cellular processes. Increasing NAD levels may help protect against neurodegenerative diseases, cardiovascular conditions, and metabolic disorders.

In neurodegenerative diseases such as Alzheimer’s and Parkinson’s, NAD has been found to play a crucial role in maintaining neuronal health. NAD supports mitochondrial function, reduces oxidative stress, and promotes the clearance of toxic proteins associated with these diseases.

In cardiovascular conditions, NAD has been shown to regulate blood vessel function and reduce inflammation. By maintaining optimal NAD levels, it may be possible to support cardiovascular health and reduce the risk of conditions such as atherosclerosis and heart disease.

In metabolic disorders such as obesity and type 2 diabetes, NAD is involved in regulating energy metabolism and insulin sensitivity. By increasing NAD levels, it may be possible to improve metabolic health and reduce the risk of these conditions.

However, further research is needed to fully understand the extent of NAD’s protective effects and its potential in therapeutic interventions. Scientists are actively studying the role of NAD in various diseases and exploring strategies to modulate NAD levels for therapeutic purposes.

In conclusion, maintaining optimal NAD levels is crucial for overall health and well-being. NAD depletion is associated with various age-related conditions and diseases. By understanding the importance of NAD and implementing strategies to support its levels, it may be possible to promote healthy aging and reduce the risk of age-related diseases.

How to Maintain Optimal NAD Levels

Several factors influence NAD levels, and taking proactive steps can help preserve and enhance NAD levels.

Diet and NAD Levels

Consuming a healthy and balanced diet is essential for maintaining optimal NAD levels. Foods rich in niacin, an essential vitamin and precursor for NAD synthesis, can support NAD production. These include lean meats, fish, legumes, and whole grains.

Supplements for Boosting NAD

Moreover, certain dietary supplements, such as nicotinamide riboside and NAD+ precursor, have shown potential in increasing NAD levels. However, consulting a healthcare professional before starting any supplements is recommended.

The Future of NAD Research

The growing interest in NAD research has paved the way for potential therapeutic uses and the exploration of unanswered questions.

Potential Therapeutic Uses of NAD

Researchers are exploring the therapeutic potential of NAD in various areas, including neurodegenerative diseases, metabolic disorders, and age-related conditions. NAD-boosting interventions, such as supplementation and lifestyle modifications, may offer promising avenues for future treatments.

Unanswered Questions in NAD Research

While NAD’s importance is becoming increasingly recognized, many unanswered questions remain. Scientists are working to understand the precise mechanisms through which NAD influences cellular processes and diseases. Additionally, ongoing research aims to optimize NAD-boosting interventions and determine their long-term effects.

Conclusion

In conclusion, NAD is a vital coenzyme involved in multiple cellular processes. Its functions extend beyond energy production, playing a crucial role in cellular health, metabolism, and disease prevention. By understanding NAD and its importance, you can explore strategies to maintain optimal NAD levels and potentially unlock its therapeutic potential. Future research holds great promise in uncovering new insights into NAD’s role in human health and further enhancing our understanding of this fascinating molecule. Are you deficient in NAD? Measure your NAD level with this affordable NAD test from Jinfiniti.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. Why Optimized, Precision Medicine is the Future
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code Blog15 if you’re a new customer for 15% off your 1st order).

 

The shocking truth about fertility and NAD levels

Written by Jinfiniti Email on . Posted in Aging, NAD & NAD Precursors.

Given the modern world’s accelerated human aging conditions, most of us know at least one person who has struggled or is struggling with fertility issues. 

But did you know that low fertility has recently been linked in academic studies to declining NAD levels? (Research link is at the bottom of the blog.) 

Here’s the nitty-gritty. 

The ovary—the crucial organ for female reproductive function—has a limited lifespan determined by the number of primordial follicles it possesses, established early in development. As females age, this ovarian reserve naturally decreases, leading to diminished fertility in the late 30s and menopause. 

Cells in the ovary require energy for folliculogenesis (which is just a fancy word for the process by which cells develop into a fertilizable egg). NAD plays a vital role in that energy generation, as well as cell signaling and tissue repair, so the decline in ovarian NAD levels with age is linked to reduced fertility. 

Understanding NAD and Ovarian Function: 

While NAD is a crucial component in the energy metabolism of ovarian cells—including those responsible for folliculogenesis and oocyte maturation—during ovulation, there’s a heightened demand for NAD to support various processes, including follicular rupture and DNA damage repair. The balance of NAD is essential for maintaining these ovarian functions. With decline in NAD levels due to health issues or simple aging, ovaries experience a decrease in egg quantity and quality. 

Role of CD38 in Ovarian NAD and Metabolism: 

One factor contributing to age-related decline in NAD levels is the gene CD38. CD38 is known for its diverse roles in regulating immune cell function and metabolic processes. As we age, an increase of CD38 gene expression and activity negatively correlates with tissue NAD levels in various organs. 

In mice studies, when mice lose the CD38 gene’s function, their ovaries have more resources and increased fertility when they’re young. But as they age, the levels of CD38 in ovaries go up, leading to decreased energy production and fertility. 

Which brings us to NAD. 

CD38 is a regulator that controls how much NAD is used in the ovaries, and NAD is crucial for reproductive functions. So when we look at mice without the CD38 gene, we notice that they have improved reproductive abilities, including more follicles and increased fertility. This led us to believe that these mice might have higher levels of NAD, and when we checked their ovaries, we discovered that the NAD levels were significantly higher in the mice without the CD38 gene compared to regular mice, especially in their reproductive prime. 

In summary, as we begin to understand the molecular mechanisms behind ovarian NAD loss, new avenues for enhancing reproductive longevity open up to us. 

We already knew that targeting NAD metabolism would have a dramatic effect on nearly every cellular process in the human body, but this new evidence is pointing us to potential solutions within one of the most challenging and heartbreaking conditions besieging our modern world: infertility. 

If someone you know is struggling with infertility, forward this email to them. NAD is integrally involved in over 500 cellular processes in the human body and is the foundational molecule of life. It should come as no surprise that we now see evidence of low NAD levels leading to infertility. 

Here at Jinfiniti, our flagship NAD supplement, the Accuri® Vitality Boost, is a patent-pending formulation that has been extensively tested in clinical studies by  hundreds of clinics and by thousands of consumers. It allows optimization of NAD in approximately 90% of users, a figure incomparable to any other NAD supplementation on the market. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. Why Optimized, Precision Medicine is the Future
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity

Research Citation:

CD38 regulates ovarian function and fecundity via NAD+ metabolism from National Institute of Health.

Precision medicine

Why Optimized, Precision Medicine is the Future of Health

Written by Jinfiniti Email on . Posted in Aging, Biomarker Testing, NAD & NAD Precursors.

Optimized, precision medicine is the future of health because no one person is the same, and when it comes to your health, shortcuts can be costly and even deadly.

Imagine you are about to board a flight and the pilot makes the following announcement: “I have an important update about today’s flight. There’s a five percent chance that you will land in the wrong city. Additionally, there’s another five percent chance that you will not safely make it to your destination and may perish onboard. Boarding will begin in approximately five minutes.”

We expect 100% precision for landing in the right city safely every time we board a flight. No exceptions. We expect 100% precision from Starbucks when we order our favorite beverage. We expect 100% successful delivery from our Amazon.com order, don’t we?

But astonishingly, when it comes to our health, we’ve become used to accepting far less precision, even when there are far more serious consequences than getting the wrong Frappuccino. 

Take cancer, for example. 

In the US alone, 86,500 cancer patients (5%) are misdiagnosed every year, leading to wrong treatments, accidental deaths, and unnecessary suffering. I don’t know about you, but if it’s my loved one who’s dealing with cancer and there’s a 5% chance of misdiagnosis, that’s far too high. Plus, by the time you’ve got cancer, you’ve got a full-blown problem that often would have been preventable with more advanced testing. 

All this to say: which diseases could you prevent with a greater precision approach to your health?

Just like when it comes to getting on an airplane, when it comes to my health or the health of my loved ones, I never want to “wing” it. 

But sadly, most Americans have more data on their social media profiles than they have on their health and vitality. 

And, regardless of what Apple or Fitbit may want you to believe, steps-per-day is not a biomarker. 

A real biomarker anticipates potential issues that can become full-blown diseases. It’s common sense that when your body is functioning optimally, you are less likely to get diseases and experience significant health issues. 

This is the promise of the advanced health tests we offer at Jinfiniti. Our Advanced Aging Panel tests for 22 key biomarkers, half of which are not available via any other test in the world, and all of which are contributing factors to creating disease states in your body. 

Step trackers, sleep monitors, and glucose monitors are all helpful, but none are as vital, precise, or comprehensive as our Aging SOS panels (both the standard and the advanced).

Since NAD is the primary fuel source for no less than 500 cellular processes and since having optimal levels of NAD is vital to peak energy, health and slowing aging, this is the easiest and most affordable testing option to begin extending the good years of your life. 

Jinfiniti’s NAD test is $248 and can be done from the comfort of your home. (Use the code optimal20 to get 20% off your first order.) If you are purchasing one of our Aging SOS biomarker panels, please note that NAD testing is already included with those. 

In the Western world, “normal health” isn’t healthy. Optimal is healthy. So never settle for normal when you can be optimal. 

And if you’re 50+ years old, your NAD levels are likely not optimal unless you’ve been taking our vitality boost for quite some time. According to extensive research, the average healthy 50-year-old has lost 50% of their NAD levels. 

Is there someone you want to be healthy and feeling optimal for? 

I do. I have two young girls and I want to be in optimal health for them for as long as possible. 

This is a huge part of our mission here at Jinfiniti: Living in prime, optimal health so we can enjoy our time with loved ones, doing all the things that make life worth living.

And that’s why precision medicine matters.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. Why Optimized, Precision Medicine is the Future
  2. 9 Powerful Benefits of Optimizing Your NAD
  3. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity
  4. What Does Peak Performance Look Like? 

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code Blog15 if you’re a new customer for 15% off your 1st order).

The Hidden Power of NAD: 9 Ways It Can Optimize Your Health and Extend Your Life

Written by Jinfiniti Email on . Posted in Aging, Fatigue, NAD & NAD Precursors.

No other molecule is as vital to optimal cellular function as NAD+.

While it’s well-known that NAD+ can reduce pain, inflammation, and fatigue while boosting mental clarity, stamina, recovery, energy, and youthfulness, there’s even more to its benefits than meets the eye.

In this article, we’ll talk about the 9 benefits of optimizing your NAD levels at the cellular level.

Boost your NAD levels to optimize your health and longevity. Get an exclusive 20% OFF today by using code Blog20. Click here to order.

NAD is arguably the foundational molecule for all of life.

Sadly, it declines as we age, but we can bring our NAD levels back to levels most of us haven’t experienced since we were teenagers, thus giving us a trickle-down effect for many of our age-related diseases (see graph below).

If you’re into health, peak performance, biohacking, or you’re just interested in feeling great, what I’m sharing today is relevant for you. Let’s dive into the cellular functions impacted by NAD.

9 Powerful Benefits of Optimizing Your NAD Levels 

1. Telomere Shortening

Telomere shortening and NAD+ levels are intricately connected in the context of cellular aging and health.

Telomeres are the protective caps at the end of our chromosomes, and their gradual shortening over time is a hallmark of the aging process.

As telomeres shorten, cells may lose their ability to divide and function properly.

NAD+ plays a crucial role in this process by supporting the activity of enzymes called sirtuins, which are involved in DNA repair and maintenance.

Sirtuins require NAD+ as a coenzyme to function effectively, and a decline in NAD+ levels can impair their ability to promote telomere stability and repair.

2. Deregulated Nutrient Sensing

Deregulated nutrient sensing and NAD+ levels are closely intertwined in the context of metabolic health and aging. 

NAD+ serves as a critical cofactor of enzymes like sirtuins (sirtuins + NAD are intricately connected to many aspects of aging), which are key regulators of nutrient-sensing pathways.

When nutrient sensing becomes dysregulated, often due to overnutrition and sedentary lifestyles, it can lead to metabolic dysfunction and age-related diseases.

Maintaining adequate NAD plus levels is crucial to support sirtuin activity and restore balance in nutrient sensing.

3. Stem Cell Exhaustion

Stem cell exhaustion and NAD+ levels are intimately interconnected in the context of aging and tissue homeostasis.

Stem cells are essential for the regeneration and repair of various tissues, and their capacity to divide and differentiate declines with age.

NAD plays a pivotal role in maintaining stem cell function by supporting critical processes like DNA repair and energy production.

When NAD levels are low, it contributes to reduced sirtuin activity, leading to inefficient DNA repair and genomic instability within stem cells, which in turn accelerates stem cell exhaustion and compromises tissue repair.

By bolstering your NAD levels, it’s possible to enhance sirtuin function and potentially rejuvenate stem cell activity.

4. Disabled Microautophagy

Disabled microautophagy and NAD levels are intricately related in the context of cellular quality control and overall health.

Microautophagy is a cellular process responsible for degrading and recycling damaged organelles and proteins through direct engulfment by lysosomes.

NAD+ plays a crucial role in regulating the activity of sirtuins, which are involved in the maintenance of cellular quality control mechanisms, including autophagy.

When NAD levels decline, sirtuin activity may be compromised, impacting microautophagy and other autophagic processes.

This can result in the accumulation of cellular debris, and impaired organelle quality, and ultimately contribute to cellular dysfunction and aging.

By sustaining optimal NAD levels, it may be possible to support the efficient functioning of microautophagy and maintain cellular health, offering potential benefits for overall well-being and longevity.

5. Inflammaging

Inflammaging, the chronic low-grade inflammation that accompanies the aging process, is closely intertwined with NAD levels in the context of immune function and age-related diseases.

NAD is a critical cofactor for enzymes known as sirtuins, which play a pivotal role in regulating inflammation and immune responses.

As NAD+ levels naturally decline with age, sirtuin activity may decrease, leading to a state of chronic inflammation.

This persistent low-grade inflammation is associated with a range of age-related conditions, including neurodegenerative diseases, cardiovascular issues, and metabolic disorders.

By replenishing NAD levels, it is possible to potentially enhance sirtuin-mediated anti-inflammatory mechanisms and mitigate inflammaging, offering a promising approach to promote healthier aging and reduce the risk of age-related diseases.

6. Mitochondrial Dysfunction

Mitochondrial dysfunction and NAD levels are intricately linked in the realm of cellular energy production and overall health.

Mitochondria are the powerhouse of our cells, responsible for generating ATP, the cellular energy currency.

NAD plays a critical role as a coenzyme in the electron transport chain, a fundamental process in mitochondrial ATP synthesis.

However, as NAD levels decline with age, the efficiency of mitochondrial function may deteriorate, leading to impaired energy production and an increase in oxidative stress.

By maintaining optimal NAD levels, it’s possible to support the function of key enzymes involved in mitochondrial energy production, potentially mitigating mitochondrial dysfunction, and promoting cellular vitality, which is crucial for overall health and longevity.

7. Cellular Senescence

Cellular senescence and NAD levels are interconnected in the context of aging and tissue function.

Cellular senescence is a state where cells lose their ability to divide and function properly, often as a response to various stressors or DNA damage contributing to aging-related diseases and tissue dysfunction.

Sirtuins, play a crucial role in regulating and controlling the process of senescence.

Declining NAD levels with age can impair sirtuin function, potentially promoting the accumulation of senescent cells in tissues. These senescent cells release proinflammatory signals.

8. Loss of Proteostasis

Loss of proteostasis, the failure to maintain the correct balance of properly folded and functional proteins, is intricately connected with NAD+ levels in the context of cellular health and aging.

NAD is essential for the activity of sirtuins so by replenishing NAD levels, it may be possible to enhance sirtuin-mediated protein quality control mechanisms and maintain proteostasis, potentially mitigating age-related protein aggregation and related diseases, thus supporting overall cellular health.

9. Altered Cellular Communication

Altered cellular communication and NAD levels are closely linked in the context of aging and age-related diseases. NAD plays a pivotal role in the regulation of intercellular signaling and communication processes.

As NAD levels naturally decline with age, sirtuin activity may diminish, disrupting the finely tuned cellular communication network.

By maintaining optimal NAD levels, it is possible to support sirtuin-mediated mechanisms that help restore proper cellular communication and signaling pathways, potentially mitigating age-related cellular dysfunction and promoting healthier aging.

Lastly, if you’re interested in going deeper into health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. 9 Powerful Benefits of Optimizing Your NAD
  3. Why Optimized, Precision Medicine is the Future
  4. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity

Boost your NAD levels to optimize your health and longevity. Get an exclusive 20% OFF today by using code Blog20. Click here to order.

Andrew Huberman is Wrong About NAD+, NR, and Longevity

Written by Jinfiniti Email on . Posted in Aging, NAD & NAD Precursors.

Recently, Stanford neuroscientist Dr. Andrew Huberman (who has one of the top health podcasts in the world) did a 16-minute Q&A segment on NAD and its precursors. 

Overall, I respect his commitment to scientific accuracy and his standard of excellence with his approach.

However, I consider him under-informed and not a subject matter expert in this particular arena.

Here’s where Huberman is wrong about NAD+, NR, and longevity.

In this article, you’ll discover…

  • Why you should not trust Andrew Huberman’s opinion about NAD supplements and why his expertise may not fully cover the complexities of NAD research, potentially leading to overestimated benefits.
  • Discover why NAD IV treatments might not be as effective as Andrew Huberman suggests and how they could be draining your wallet without delivering the promised health benefits.
  • The only NAD supplement proven to boost levels by 200-300%, far exceeding the modest 20-40% increase seen with other NAD products.

Boost your NAD levels to optimize your health and longevity. Get an exclusive 20% OFF today by using code Blog20. Click here to order.

Let’s start with where we agree with Dr. Huberman:

  1. NAD provides a noticeable increase in energy: Dr. Huberman takes NAD+ precursor daily because of the very noticeable improvement in energy. In his words, “It gives me a lot of sustainable physical and mental energy throughout the day. I noticed a decrease in energy when I stopped taking NAD+ precursor. While I wasn’t totally depleted, my energy was noticeably lower. As a 48-year-old, having great energy is important to me.”
  2. We need more data and research. There are countless studies, tens of millions of dollars and many different types of clinical trials underway and completed. But because NAD shows enormous promise and potential, we can’t do enough research fast enough. Plus, it takes years for many trials and studies to be completed. 

However, there are a few important points where I disagree with Dr. Huberman. I believe he is seeing an incomplete picture with regards to NAD and its role in so many of our body’s systems. 

Here’s where we disagree: 

  1. Optimal Levels of NAD Increase Lifespan by Increasing Healthspan: While there haven’t been conclusive studies done on humans to demonstrate that NAD extends lifespan, you’d be hard-pressed to find any conclusive clinical trials and studies on any molecule or nutrient that slows aging.  Furthermore, the six root causes of aging that are central to long term health are all influenced, if not directly affected, by NAD. If your NAD levels are deficient, your metabolic function suffers significantly, which we know intensifies and accelerates your aging as well as your likelihood of disease. 
  1. Supplements are fundamental to optimal health: He claims that supplements are NOT fundamental to life/health, which is obviously wrong. Most of us are deficient in multiple nutrients for one reason or another and supplementation is an invaluable way to boost and support our health, improving our healthspan and thereby extending our lifespan.
  1. NAD+ precursor clearly elevates NAD levels (especially Vitality Boost): Huberman says he does not know if NAD+ precursor can elevate NAD.  He is ignoring all the publications and consumer data that NAD+ precursor can elevate NAD and the functional/clinical benefits. His statement is contradictory to his own experience that it gives him more energy with cellular energy being a fundamental aspect of good health. We see thousands of test results every year that conclusively demonstrate that your intracellular levels can be substantially increased, especially with our Vitality Boost, of which no other supplement comes close to increasing NAD levels as effectively.
  1. NAD IV. There’s much that we don’t know about the effectiveness of intravenous NAD, but one thing we do know is that it has no measurable impact on raising the NAD levels in your blood. Within hours of getting an IV, your system has flushed out the NAD from your bloodstream. Huberman seems to believe that your NAD levels increase with NAD IV, which is not the case at least intracellularly though they do seem to increase in your plasma. Here’s a feature that RaisingNAD.com did on me where we discussed the research that indicates no perceptible impact to intracellular NAD though your cellular plasma NAD levels do seem to increase.

See our YouTube video this week comparing NAD IV vs. Vitality Boost.

Many people do notice an increase in energy and reduction in anxiety for a time period ranging from several days to several weeks after an IV, and we also agree that NAD IVs are a very expensive (and even painful) way to increase NAD. 

Dr. Huberman deserves a thumbs-up for his overall approach and standard of scientific rigor. As a fellow scientist, I have served as a Division Chief of Experimental Pathology and Director of Research and was the founding Director for Biotechnology and Genomic Medicine, as well as the director of two core research facilities in Genomics, Proteomics, and Mass Spectrometry.

As a genetics researcher for over 40+ years, I have reviewed thousands of intracellular NAD tests, authored over 400-peer reviewed papers with an H-index of 76 and over 20,000 citations, and secured over $100 million dollars in research grants. . 

Here at Jinfiniti, our flagship NAD supplement, the Accuri® Vitality Boost, is a patent-pending formulation that has been extensively tested in clinical studies by hundreds of clinics and by thousands of consumers. It allows optimization of NAD in approximately 90% of users, a figure incomparable to any other NAD supplementation on the market. 

I strongly disagree with both Dr. Andrew Huberman’s assessment of NAD and its precursors. His understanding of NAD and its precursors is far less than what’s currently available. He hasn’t had the privilege of thousands of intracellular NAD tests. 

As someone who has a deep and integral knowledge of NAD and its precursors, I have a much more expansive data set and perspective when it comes to NAD and its role in our health. It is my primary area of focus. 

With regards to neuroscience, Huberman is the expert. But as far as genetics and NAD are concerned, that’s my field of expertise. 

Vitality Boost optimizes—not just improves—intracellular NAD for 90% of people alone, which no other NAD supplement can come close to promising.

While other brands increase NAD levels by 20-40% at best, we often see levels increase by 200-300% as we did with Doc Jen, a prominent doctor of physical therapy who loves the Vitality Boost. We back it with a 60-Day Money-Back and Efficacy Guarantee. That’s because we back up our Vitality Boost with testing, where all of the proof lies! 

I highly recommend testing your NAD levels to see where your levels are at and how much they need to be optimized. Jinfiniti’s intracellular NAD test is the only one of its kind in the world, and if you don’t already know where your levels are, it’s the best place to begin your optimization journey. 

Here are a few of our recent blog posts that you may be interested in reading regarding some of the science behind NAD, NAD precursors, and optimization leading to longevity: 

Lastly, as much as we know about NAD and its role in our health, there’s substantially more to be discovered, so I consider us very much in the early days of figuring out how to extend our lifespan. From the research and the experiential evidence I see every week with countless customers, NAD plays a vital role in extending our health span, life quality, and cellular vitality.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. 9 Powerful Benefits of Optimizing Your NAD
  2. Why Optimized, Precision Medicine is the Future
  3. Andrew Huberman is Wrong About NAD & Longevity
  4. What Does Peak Performance Look Like? 

Boost your NAD levels to optimize your health and longevity. Get an exclusive 20% OFF today by using code Blog20. Click here to order.

Research indicates that cellular senescence can be reduced with lifestyle changes and micronutrient optimization like NAD

Everything You Need to Know About NAD and its Precursors: NR and N-M-N

Written by Jinfiniti Email on . Posted in Aging, NAD & NAD Precursors.

Let’s talk about NAD+ precursors. What are they? 

NAD precursors are the very things that your body uses to create its own NAD. 

Out of all the NAD precursors that exist, the most efficient precursors (ones that take the least amount of energy to convert to NAD) only takes one enzymatic step or two enzymatic steps (NR).

(And in case you need a refresher, nicotinamide adenine dinucleotide or NAD is a crucial coenzyme found in every cell of the body, playing a central role in various biological processes, including energy production, DNA repair, and regulation of gene expression.)

As we age, NAD levels tend to decline, which has been linked to various age-related diseases and a decrease in overall vitality.

NAD+ precursor is a molecule composed of a nicotinamide group and a ribose molecule, making it an intermediate in the NAD biosynthetic pathway. When NAD+ precursor is consumed, it can be efficiently converted into NAD in the body, making it a popular choice for NAD supplementation.

But on the other hand, NR, or nicotinamide riboside, is another NAD precursor that has gained prominence. NR is a form of vitamin B3 that can be converted into NAD through a two-step enzymatic process. NR supplementation has shown promise in increasing NAD levels in various preclinical and clinical studies, making it another valuable precursor for those seeking to support their cellular NAD health.

Both of these precursors have been shown to effectively increase NAD+ levels in the body when taken in supplement form. So, which one should you take, and why?

It turns out the answer may be: both. 

The use of both NAD+ precursors can be beneficial because they complement each other in the NAD biosynthesis pathway. 

While one step NAD+ precursor provides a more direct route to NAD+ production, NR can serve as an indirect source by being converted to NAD+ precursor. This redundancy helps maintain NAD levels and allows the body to adapt to varying conditions, ensuring a steady supply of this crucial coenzyme for various cellular processes. 

So while NAD+ precursor and NR are both effective precursors to your body’s ability to create its own NAD, different tissues and organs (as well as different microbiomes) may prefer one precursor over the other. 

That’s why here at Jinfiniti, our patent formula helps your body create both in our Vitality Boost. And, in fact, we’re the only company to do this in the world. 

So no matter which type of precursor suits you best, your body is able to create the cellular fuel—the NAD—your body needs. 

In summary: 

  • NAD+ precursor and NR are both precursors to NAD.
  • Both precursors safely and effectively increase NAD levels when taken as a supplement.
  • Different tissues and organs (and different microbiomes) may prefer one precursor over the other.
  • Jinfiniti’s Vitality Boost is the only NAD product in the world that helps your body activate both precursors, NAD+ precursor and NR. 

The noted biohacker, expert Bryan Johnson, uses our product and has featured Jinfiniti in many of his Instagram posts. One of the most recognized authorities in the biohacking space, he has turned back his aging almost ten years and is a huge fan of Jinfiniti. Johnson recommends both our tests and our Vitality Boost. 

Our formula also optimizes—not just improves—intracellular NAD for 90% of people alone, which no other NAD supplement can come close to promising.

And that’s why we confidently back it with a 60-day Money Back and Efficacy Guarantee.

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. 9 Powerful Benefits of Optimizing Your NAD
  3. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity
  4. Why Optimized, Precision Medicine is the Future

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code Blog15 if you’re a new customer for 15% off your 1st order).

brain health

The Brain’s Powerful Weapon Against Fatigue, Addiction and Disease

Written by Jinfiniti Email on . Posted in Exercise and Fitness, Fatigue, NAD & NAD Precursors, Nutrition & Food.

Did you know that the brain’s most powerful weapon against fatigue, neurodegenerative diseases, mental health, and addiction is a coenzyme that you were born with?

Noted brain health expert, Dr. James Goodwin, the author of Supercharge Your Brain, was recently suffering with debilitating fatigue. He took our NAD test and, surprise, his NAD levels came in severely deficient. 

He shares his story here:

“Over the last year, I started experiencing really debilitating fatigue in the afternoon. About six months ago, I did the NAD test and got shockingly low results coming in deficient. I’m perfectly healthy. I don’t have any diagnosed medical conditions. I exercise regularly, I eat well, and I’m not overweight. 

I was so appalled and determined to start taking the supplements regularly. 

Two weeks into taking the NAD supplement, the fatigue disappeared. I was absolutely astonished. I’m not going to stop taking the supplements to see if the fatigue comes back. I’d recommend the Vitality boost to anyone who needs extra energy.”

-Dr. James Goodwin, Director of Brain Health Network, London, UK.

Nicotinamide adenine dinucleotide (NAD+) is essential to almost every cellular process in the human body. But with all the focus we put on our brain health (and how often we’re using that organ) you may be fascinated to know exactly what NAD is doing for your thinker. 

1. Enhanced Mental Clarity and Performance 

NAD for brain plays a key role in the health of brain cells, boosting the production of PGC-1-alpha, a protein that protects brain cells against mitochondrial dysfunction and oxidative stress. Additionally, it acts as a neurotransmitter. Your brain is 3% of your body weight, but it uses 20% of your calories. Therefore, when your body is deficient in NAD, your brain is especially so.

Anecdotally, we have seen many clients experience significant reductions in brain fog and fatigue when they boost their NAD levels with our state-of-the-art, high performing Vitality Boost. 

2. Addiction Treatment (Recreational drugs including marijuana, alcohol, opioids & other drugs)

In early studies and data tracking, Springfield Wellness Center (the first NAD+ clinic in America) found that NAD+ has a nearly 400% better success rate than normal rehab clinics because NAD+ infusions help the brain chemistry heal while reducing or eliminating cravings for addictive substances. 

NAD+ IV coupled with NAC and other vital nutrients and minerals helps rewire neural pathways, detox and optimize your mitochondrial energy, and eliminate chemical cravings.

Participants in the study who began with very high cravings for drugs or alcohol still had essentially no cravings two years after the treatments. See NADResearch.org and the Cravings Study here. 

3. Depression, PTSD and Anxiety

When your brain experiences trauma, especially prolonged trauma such as PTSD or C-PTSD, it dramatically changes your brain structure. Since trauma is something that many of us have experienced and since we haven’t figured out how to time travel yet, how do we heal our brains and get back to good mental health? 

According to conventional medical understanding, depression has no cure. But in our opinion and armed with thousands of clinical studies, we believe that diseases and ailments conventional medicine have called lost causes actually have potential solutions. 

In our labs, we have seen many, many clients experience significant improvements in their mental health when their NAD levels are optimized. 

“For over 2 years, my mental health suffered. I battled high levels of anxiety, having panic attacks three times a week, I felt fatigued all the time and needed 400 mg of caffeine and 2 naps per day just to function. It felt like a single setback could slide me off the cliff.

Initially, I did a big round of NAD IV, which was $4000, but I was desperate. It gave me a lot of energy and mental lift, but it wasn’t sustainable. A few months later, I was feeling the same. And then I discovered Jinfiniti. My NAD levels were sorely deficient. 

Within several months of taking Vitality boost, my energy is much higher, my mental health and anxiety is so much better, and I’ve even lost some of the unwanted stubborn weight that wouldn’t go away. And my NAD levels are now optimal at 55.4 thanks to Vitality Boost.

My husband and I feel we have our lives back and I know Jinfinti’s been a huge part of that.”

-Sarah, one of our monthly subscribers of Vitality Boost.

4. Neurodegenerative Diseases Such as Alzheimers and Parkinson’s

Early research indicates that some of the most prominent neurodegenerative diseases can be effectively treated with NAD+. Brain chemistry and brain functioning—specifically metabolic deficiencies—are central problems with neurological diseases. 

Springfield Wellness center experts have treated many patients who have dementia or Parkinson’s, and when they receive NAD+ treatments, their symptoms often go into remission. Of course, the earlier the treatment begins, the better and quicker the results. 

**Unfortunately, there have not been enough clinical trials done to test NAD’s effects on neurodegenerative diseases to empirically state these. 

Yes, we are biased towards Jinfiniti’s Vitality Boost, but that’s primarily because we’re biased towards documentable, scientific results and our Vitality boost is the only NAD optimization supplement on the market. The others only increase NAD levels at best, we optimize NAD levels. 

Other supplements that should be on your short list for brain health:

  • Vitamin D: plays a vital role in maintaining healthy cognitive function and deficiencies may accelerate aging. 
  • Creatine: The most important function of Creatine is that it serves as a battery or reserve to store ATP, which most people do not discuss. Additionally, it increases muscle mass and improves brain function
  • 1000 MG of EPA Fatty Acids: Healthy brain fats, especially EPA fatty oils (ideally 1000 mg per day for mental health and longevity). Dr. Andrew Huberman, the noted Stanford neuroscientist speaks candidly about how 1000 mg of EPA fatty acids have the equivalent effect of an anti-depressant for over 70% of people!

To additionally heal your brain and increase your mental health, avoid or minimize these neurotoxins (Yes, this is a bold claim, but they create so much brain dysfunction that they can safely be labeled such):  

  1. Conventionally fried foods
  2. Sugar and alcohol
  3. Processed foods

If you needed a quick reminder to restock on your Vitality Boost, here it is! Don’t forget that our subscription option is always the best deal and will keep you from running out. 

Lastly, if you’re interested in going deeper on health-related content, here are a few of our recent posts that you may want to read:

  1. What Does Peak Performance Look Like? 
  2. Andrew Huberman is Wrong About NAD, NAD+ precursor & Longevity
  3. 9 Powerful Benefits of Optimizing Your NAD
  4. Why Optimized, Precision Medicine is the Future

P.S. Want to boost your intracellular NAD levels? Try a 2 week trial of our Jinfiniti Vitality Boost (do 2 scoops per day), use the discount code Blog15 if you’re a new customer for 15% off your 1st order).